If there was ever any doubt about whether or not the "real" E3 was back after the subdued 2007 and 2008 shows, this list should end it. We've put together a massive list of all the confirmed games you can expect to see coming out of E3 2010. Keep in mind, however, that there's bound to be tons more that are being held tightly under wrap. (Courtesy of Game Informer)

2K Games
Civilization V (PC)
Mafia II (PS3, 360, PC)
Spec Ops: The Line (PS3, 360, PC)
X-Com (360, PC)

505 Games
Grease (Wii, DS)
Naughty Bear (PS3, 360)

Activision
Call of Duty: Black Ops (PS3, 360, Wii, PC)
DJ Hero 2 (PS3, 360, Wii)
Guitar Hero: Warriors of Rock (PS3, 360, Wii)
Spider-Man: Shattered Dimensions (PS3, 360, Wii, DS)
True Crime (PS3, 360, PC)

Follow up:

Atari
Blade Kitten (XBLA, PSN)
Test Drive Unlimited 2 (PS3, 360, PC)
The Witcher 2: Assassins of Kings (PC)

Atlus
Etrian Odyssey III (DS)
Knights in the Nightmare (PSP)
Rock of Ages (TBA)
Trine 2 (TBA)

Bethesda
Brink (PS3, 360, PC)
Fallout: New Vegas (PS3, 360, PC)
Hunted: The Demon's Forge (PS3, 360, PC)
Rage (PS3, 360, PC)

Capcom
Bionic Commando: Rearmed 2 (XBLA, PSN)
Dead Rising 2 (PS3, 360, PC)
Ghost Trick: Phantom Detective (DS)
Marvel vs. Capcom 3 (PS3, 360)
Okamiden (DS)
Sengoku BASARA: Samurai Heroes (PS3)

Codemasters
Bodycount (PS3, 360)
F1 2010 (PS3, 360, PC)

Disney
Epic Mickey (Wii)
Guilty Party (Wii)
Pirates of the Carribean: Armada of the Damned (PS3, 360, PC)
Toy Story 3: The Video Game (PS3, 360, PC)
Tron: Evolution (PS3, PC)

Electronic Arts
APB: All Points Bulletin (PC)
Bulletstorm (PS3, 360, PC)
Crysis 2 (PS3, 360, PC)
Dead Space 2 (PS3, 360, PC)
EA Sports Active 2.0 (Wii)
EA Sports MMA (PS3, 360)
FIFA Soccer 11 (PS3, 360, Wii, DS, PSP, PC)
Madden NFL 11 (PS3, 360, Wii, DS, PSP, PS2, PC)
Medal of Honor (PS3, 360, PC)
Monopoly Streets (PS3, 360, Wii, DS)
NBA Jam (Wii)
NCAA Football 11 (PS3, 360, PS2)
NHL 11 (PS3, 360)
NHL Slapshot (Wii)
Rock Band 3 (PS3, 360, Wii)
Tiger Woods PGA Tour 11 (PS3, 360, Wii)
The Sims 3: Ambitions (PC)
The Sims 3 (PS3, 360)

Ignition
Blacklight: Tango Down (PS3, 360, PC)
El Shaddai (PS3, 360)

Konami
Castlevania: Lords of Shadow (PS3, 360)
Def Jam Rapstar (PS3, 360, Wii)
Lucha Libre AAA: Heroes Del Ring (PS3, 360, Wii, PSP)
Metal Gear Solid: Rising (PS3, 360, PC)
Ninety-Nine Nights II (360)
Pro Evolution Soccer 2011 (PS3, 360)
Rush 'N Attack: Ex-Patriot (XBLA, PSN)
Saw II (PS3, 360)
Silent Hill (TBA)
The Cages: Pro Style Batting Practice (Wii)

LucasArts
Lego Star Wars III (PS3, 360, Wii, DS, PSP, PS2, PC)
Monkey Island 2 SE (PS3, 360, PC)
Star Wars: The Force Unleashed II (PS3, 360, Wii, DS, PSP, PC)
Star Wars: The Old Republic (PC)

Majesco
Babysitting Mama (Wii)
Crafting Mama (DS)
Greg Hastings Paintball 2 (PS3, 360, Wii)
Monster Tale (DS)
Swords (Wii)
Zumba Fitness (Wii)

Microsoft
Fable III (360, PC)
Gears of War 3 (360)
Halo: Reach (360)
Project Natal (360)

Namco Bandai
Ace Combat: Joint Assault (PSP)
Clash of the Titans (PS3, 360)
Enslaved (PS3, 360)
Dragon Ball: Origins 2 (DS)
Naruto: Ultimate Ninja Storm 2 (PS3, 360)
Pac Man 2010 (TBA)
Splatterhouse (PS3, 360)

Natsume
Gabrielle's Ghostly Groove (DS)
Harvest Moon: Grand Bazaar (DS)
Lufia: Curse of the Sinistrals (DS)
Rune Factory 3: A Fantasy Harvest Moon (DS)

Nintendo
3DS
Metroid: Other M (Wii)
Wii Party (Wii)
Zelda (Wii)

Sega
Phantasy Star Portable 2 (PSP)
The Conduit 2 (Wii)
Tournament of Legends (Wii)
Total War: Shogun 2 (PC)
Sonic the Hedgehog 4: Episode 1 (XBLA, PSN)
Sonic Colors (Wii, DS)
Valkyria Chronicles II (PSP)
Vanquish (PS3, 360)

Sony
DC Universe (PS3, PC)
EyePet (PS3)
Free Realms (PS3, PC)
God of War: Ghost of Sparta (PSP)
Gran Turismo 5 (PS3)
Hot Shots Tennis: Get a Grip (PSP)
Invizimals (PSP)
Killzone 3 (PS3)
LittleBigPlanet 2 (PS3)
Move Party (PS3)
Playstation Move
SOCOM 4 (PS3)
Sports Champions (PS3)
Slider (PS3)
TV Superstars (PS3)
The Fight: Lights Out (PS3)
The Last Guardian (PS3)
The Shoot (PS3)

Southpeak
Nail'd (PS3, 360, PC)
Two Worlds II (PS3, 360, PC)

Square Enix
Deus Ex: Human Revolution (PS3, 360, PC)
Dungeon Siege 3 (PS3, 360, PC)
Final Fantasy XIV (PS3, PC)
Final Fantasy: The 4 Heroes Of Light (DS)
Front Mission Evolved (PS3, 360, PC)
Kane & Lynch 2: Dog Days (PS3, 360, PC)
Kingdom Hearts: Birth By Sleep (PSP)
Kingdom Hearts: Re:coded (DS)
Lara Croft and the Guardian of Light (XBLA, PSN)
The 3rd Birthday (PSP)

Ubisoft
Assassin's Creed: Brotherhood (PS3, 360, PC)
R.U.S.E. (PS3, 360, PC)
Shaun White Skateboarding (PS3, 360, Wii, PC)
Tom Clancy's Ghost Recon: Future Soldier (PS3, 360, Wii, DS, PSP, PC)
Tom Clancy's HAWX 2 (PS3, 360, PC)

Valve
Portal 2 (360, PC, Mac)

Warner Bros
Batman: The Brave And The Bold (Wii, DS)
F.E.A.R. 3 (PS3, 360, PC)
Lego Harry Potter: Years 1-4 (PS3, 360, Wii, DS, PSP, PC)
Lego Universe (PC)
Mortal Kombat (PS3, 360)
Scooby Doo and the Spooky Swamp (Wii, DS, PS2)
Super Scribblenauts (DS)
The Legend of the Guardians: The Owls of Ga'Hoole (PS3, 360, Wii, DS)
The Lord of the Rings: Aragorn's Quest (TBA)
The Lord of the Rings: War in the North (PS3, 360, PC)
Vacation Isle: Beach Party (Wii)